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Thomas R Korfhagen Selected Research

Transforming Growth Factor alpha (TGF-alpha)

7/2010Signaling pathways in the epithelial origins of pulmonary fibrosis.
2/2010Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.
11/2009Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
10/2009Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
8/2009Surfactant-associated protein B is critical to survival in nickel-induced injury in mice.
6/2008EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
9/2007Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
8/2007Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.
4/2004Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.
11/2003Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.
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Thomas R Korfhagen Research Topics

Disease

9Inflammation (Inflammations)
05/2015 - 02/2002
9Pulmonary Fibrosis (Fibrosing Alveolitis)
04/2014 - 04/2004
8Fibrosis (Cirrhosis)
04/2014 - 03/2003
7Lung Diseases (Lung Disease)
01/2014 - 10/2002
7Lung Injury
02/2013 - 03/2002
5Pneumonia (Pneumonitis)
11/2013 - 02/2002
4Asthma (Bronchial Asthma)
05/2015 - 10/2009
4Pulmonary Hypertension
10/2009 - 11/2003
4Acute Lung Injury
08/2009 - 03/2002
3Metaplasia
02/2014 - 03/2011
3Infections
10/2012 - 02/2004
3Weight Loss (Weight Reduction)
02/2010 - 06/2008
3Emphysema
08/2006 - 10/2002
2Sepsis (Septicemia)
01/2018 - 02/2002
2Respiratory Hypersensitivity
05/2015 - 10/2009
2Cachexia
04/2014 - 09/2007
2Hyperplasia
11/2013 - 04/2007
2Interstitial Lung Diseases (Interstitial Lung Disease)
02/2013 - 07/2009
2Respiratory Syncytial Virus Infections
02/2013 - 07/2009
2Virus Diseases (Viral Diseases)
02/2013 - 07/2009
2Body Weight (Weight, Body)
12/2011 - 04/2004
2Chronic Obstructive Pulmonary Disease (COPD)
11/2009 - 04/2008
2Vascular Remodeling
06/2008 - 11/2003
2Pulmonary Edema
04/2002 - 03/2002
1Airway Remodeling
12/2011
1Persistent Infection
02/2010
1Pseudomonas Infections
07/2008
1Idiopathic Pulmonary Fibrosis
09/2007
1Bronchopulmonary Dysplasia
08/2007
1Vascular Diseases (Vascular Disease)
11/2003
1Pulmonary Emphysema
10/2002
1Lipidoses
10/2002
1Edema (Dropsy)
04/2002
1Genetic Predisposition to Disease (Genetic Predisposition)
03/2002
1Pulmonary Atelectasis
03/2002

Drug/Important Bio-Agent (IBA)

11Surface-Active Agents (Surfactants)IBA
11/2013 - 02/2002
11Transforming Growth Factor alpha (TGF-alpha)IBA
07/2010 - 04/2002
8Proteins (Proteins, Gene)FDA Link
04/2014 - 03/2002
6ErbB Receptors (EGF Receptor)IBA
04/2014 - 11/2003
5CollagenIBA
12/2011 - 04/2004
4Transcription Factors (Transcription Factor)IBA
05/2015 - 10/2009
4Protein CIBA
11/2013 - 07/2008
4CytokinesIBA
11/2013 - 04/2004
4MucinsIBA
11/2009 - 04/2007
3Methacholine Chloride (Methacholine)FDA Link
05/2015 - 10/2009
3Doxycycline (Periostat)FDA LinkGeneric
04/2014 - 06/2008
3Transforming Growth Factors (Transforming Growth Factor)IBA
04/2014 - 11/2003
3Pulmonary Surfactant-Associated Protein CIBA
11/2013 - 07/2009
3Phospholipids (Phosphatides)FDA LinkGeneric
10/2002 - 02/2002
2Toll-Like Receptors (Toll-Like Receptor)IBA
01/2018 - 10/2012
2LigandsIBA
01/2018 - 04/2014
2Sirolimus (Rapamycin)FDA Link
12/2011 - 11/2009
2Messenger RNA (mRNA)IBA
12/2011 - 07/2009
2Erlotinib Hydrochloride (CP 358,774)FDA Link
03/2011 - 06/2008
2Acrolein (Aqualin)IBA
11/2009 - 04/2008
2Cysteine (L-Cysteine)FDA Link
11/2009 - 09/2007
2AllergensIBA
10/2009 - 04/2007
2NickelIBA
08/2009 - 04/2002
2LipidsIBA
08/2006 - 10/2002
2Interleukin-6 (Interleukin 6)IBA
04/2004 - 04/2002
2Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
03/2003 - 10/2002
1IntegrinsIBA
04/2014
1Antiviral Agents (Antivirals)IBA
02/2014
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2014
1ResistinIBA
06/2012
1Bleomycin (Blenoxane)FDA LinkGeneric
06/2012
1Silicon Dioxide (Silica)FDA LinkGeneric
06/2012
1Fibronectins (Fibronectin)IBA
12/2011
1Therapeutic UsesIBA
12/2011
1Anti-Bacterial Agents (Antibiotics)IBA
02/2010
1PX-866IBA
02/2010
1HemopexinIBA
11/2009
1TOR Serine-Threonine KinasesIBA
11/2009
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
11/2009
1Toll-Like Receptor 3IBA
07/2009
1Alcian BlueIBA
07/2008
1Gefitinib (Iressa)FDA Link
06/2008
1Tyrosine Kinase InhibitorsIBA
06/2008
1Extracellular Matrix ProteinsIBA
09/2007
1Endothelin Receptors (Endothelin Receptor)IBA
09/2007
1TenascinIBA
09/2007
1CaveolinsIBA
09/2007
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
09/2007
1OsteopontinIBA
09/2007
1Protease Inhibitors (Protease Inhibitor)IBA
09/2007
1Serine (L-Serine)FDA Link
09/2007
1Growth Factor ReceptorsIBA
08/2007
1Interleukin-13IBA
04/2007
1Metalloproteases (Metalloproteinases)IBA
08/2006
1Phosphatidylcholines (Phosphatidylcholine)IBA
08/2006
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2004
1Transforming Growth Factor beta (TGF-beta)IBA
04/2004
1mouse lysozyme MIBA
02/2004
1Muramidase (Lysozyme)IBA
02/2004
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2003
1ElastinIBA
03/2003
1InterleukinsIBA
04/2002
1IgA receptor (protein B)IBA
04/2002
1Complementary DNA (cDNA)IBA
03/2002

Therapy/Procedure

2Therapeutics
12/2011 - 02/2010